Critics of the Book of Mormon frequently argue that genetic studies showing American Indian ancestry tracing largely to Asia disprove the book’s historical claims, which describe an ancient Near Eastern group among the ancestors of some Native American populations. However, using this fact alone to dismiss the Book of Mormon is methodologically flawed. Population genetics is highly complex, especially when dealing with small migrant groups, genetic drift, bottlenecks, and the loss of identifiable DNA markers over thousands of years. The Book of Mormon itself does not claim that all Indigenous peoples descend exclusively from Middle Eastern migrants, but that a limited group was present and later absorbed into much larger populations. Drawing sweeping conclusions from incomplete genetic data relies on assumptions that oversimplify both the text and the science. Despite these limitations, DNA arguments are frequently repeated by LDS critics, often without acknowledging these complexities, contributing to confusion and doubt rather than careful historical or scientific analysis.